Membrane Type 1–Matrix Metalloproteinase/Akt Signaling Axis Modulates TNF-α-Induced Procoagulant Activity and Apoptosis in Endothelial Cells

Membrane type 1–matrix metalloproteinase (MT1-MMP) functions as a signaling molecule in addition to a proteolytic enzyme. Our hypothesis was that MT1-MMP cooperates with protein kinase B (Akt) in tumor necrosis factor (TNF)-α-induced signaling pathways of vascular responses, including tissue factor...

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Autors principals: Ohkawara, Hiroshi, Ishibashi, Toshiyuki, Sugimoto, Koichi, Ikeda, Kazuhiko, Ogawa, Kazuei, Takeishi, Yasuchika
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4146507/
https://ncbi.nlm.nih.gov/pubmed/25162582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105697
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