Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue.

A potent, orally active growth hormone (GH) secretagogue L-163,191 belonging to a recently synthesized structural class has been characterized. L-163,191 releases GH from rat pituitary cells in culture with EC50 = 1.3 +/- 0.09 nM and is mechanistically indistinguishable from the GH-releasing peptide...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Patchett, A A, Nargund, R P, Tata, J R, Chen, M H, Barakat, K J, Johnston, D B, Cheng, K, Chan, W W, Butler, B, Hickey, G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41459/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7624358/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.15.7001
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