Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue.

A potent, orally active growth hormone (GH) secretagogue L-163,191 belonging to a recently synthesized structural class has been characterized. L-163,191 releases GH from rat pituitary cells in culture with EC50 = 1.3 +/- 0.09 nM and is mechanistically indistinguishable from the GH-releasing peptide...

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Bibliographische Detailangaben
Hauptverfasser: Patchett, A A, Nargund, R P, Tata, J R, Chen, M H, Barakat, K J, Johnston, D B, Cheng, K, Chan, W W, Butler, B, Hickey, G
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1995
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC41459/
https://ncbi.nlm.nih.gov/pubmed/7624358
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