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Comparison of effects of anti-angiogenic agents in the zebrafish efficacy–toxicity model for translational anti-angiogenic drug discovery

BACKGROUND: Anti-angiogenic therapy in certain cancers has been associated with improved control of tumor growth and metastasis. Development of anti-angiogenic agents has, however, been saddled with higher attrition rate due to suboptimal efficacy, narrow therapeutic windows, or development of organ...

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Detalhes bibliográficos
Main Authors: Chimote, Geetanjali, Sreenivasan, Jayasree, Pawar, Nilambari, Subramanian, Jyothi, Sivaramakrishnan, Hariharan, Sharma, Somesh
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145829/
https://ncbi.nlm.nih.gov/pubmed/25170251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S55621
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