CLONAL EVOLUTION OF GLIOMAS IS ENCODED IN THE EVOLUTIONARY DYNAMICS OF DNA METHYLATION

BACKGROUND: The clonal evolution of tumor cell populations can be reconstructed from patterns of genetic alterations. In contrast, tumor epigenetic states are reversible and sensitive to the tumor microenvironment, presumably precluding the use of epigenetics to discover the clonal and sub-clonal ev...

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Autori principali: Costello, Joseph F., Mazor, Tali, Pankov, Alex, Johnson, Brett E., Hong, Chibo, Bell, Robert J.A., Smirnov, Ivan V., Reis, Gerald F., Phillips, Joanna J., Barnes, Michael, Bollen, Andrew W., Taylor, Barry S., Molinaro, Annette M., Olshen, Adam B., Song, Jun S., Berger, Mitchel S., Chang, Susan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144653/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou209.38
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