A PHASE III RANDOMIZED CONTROLLED TRIAL OF SHORT-COURSE RADIOTHERAPY WITH OR WITHOUT CONCOMITANT AND ADJUVANT TEMOZOLOMIDE IN ELDERLY PATIENTS WITH GLIOBLASTOMA (NCIC CTG CE.6, EORTC 26062-22061, TROG 08.02, NCT00482677)

BACKGROUND: The EORTC (26981-22981)/NCIC CTG (CE.3) RCT in newly diagnosed GBM showed increased survival with concomitant and adjuvant temozolomide (TMZ) added to radiotherapy (RT). Study pts were 18-71 (median 56) years; however a sub-group analysis noted a trend of decreasing benefit from the addi...

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Autori principali: MD, James R. Perry, O'Callaghan, Christopher J., Ding, Keyue, Roa, Wilson, Mason, Warren P., Cairncross, J. Gregory, Brandes, Alba Ariela, Menten, Johan, Phillips, Claire, Fay, Michael F., Nishikawa, Ryo, Winch, Chad, Laperriere, Normand
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144629/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou209.16
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