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TERT PROMOTER MUTATIONS CONTRIBUTE TO PROGNOSTIC SUBGROUPS OF LOWER GRADE ASTROCYTOMAS
BACKGROUND: Recurrent mutations in the promoter region of TERT (telomerase reverse transcriptase) have been found in various cancers including diffuse gliomas. Mutations lead to TERT upregulation and are associated with aggressive clinical behaviour in glioblastomas. However, the prognostic impact o...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4144625/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou209.12 |
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