WHOLE EXOME SEQUENCING IDENTIFIED THAT THE MAPK AND PI3K PATHWAYS ARE THE MAIN TARGETS FOR MUTATIONS IN INTRACRANIAL GERM CELL TUMORS

BACKGROUND: Intracranial germ cell tumors (iGCTs) are rare in the Western countries, however they are the second most common brain tumors in patients under 14 in Japan. Unlike other common pediatric brain tumors, the biology of iGCTs is largely unknown. METHODS: We performed a whole exome sequencing...

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Auteurs principaux: Ichimura, Koichi, Fukushima, Shintaro, Totoki, Yasushi, Matsushita, Yuko, Otsuka, Ayaka, Tomiyama, Arata, Niwa, Tohru, Sakai, Ryuichi, Ushijima, Toshikazu, Nakamura, Taishi, Suzuki, Tomonari, Fukuoka, Kouhei, Yanagisawa, Takaaki, Mishima, Kazuhiko, Nakazato, Yoichi, Hosoda, Fumie, Narita, Yoshitaka, Shibui, Soichiro, Yoshida, Akihiko, Takami, Hirokazu, Mukasa, Akitake, Aihara, Koki, Saito, Nobuhito, Kumabe, Toshihiro, Kanamori, Masayuki, Tominaga, Teiji, Kobayashi, Keiichi, Shimizu, Saki, Nagane, Motoo, Iuchi, Toshihiko, Mizoguchi, Masahiro, Yoshimoto, Koji, Tamura, Kaoru, Maehara, Taketoshi, Sugiyama, Kazuhiko, Nakada, Mitsutoshi, Sakai, Keiichi, Kanemura, Yonehiro, Yokogami, Kiyotaka, Takeshima, Hideo, Kawahara, Nobutaka, Takayama, Tatsuya, Yao, Masahiro, Matsutani, Masao, Shibata, Tatsuhiro, Nishikawa, Ryo
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144564/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou208.2
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