HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance

Proinflammatory cytokines play important roles in insulin resistance. Here we report that mice with a T-cell-specific conditional knockout of HGK (T-HGK cKO) develop systemic inflammation and insulin resistance. This condition is ameliorated by either IL-6 or IL-17 neutralization. HGK directly phosp...

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Hlavní autoři: Chuang, Huai-Chia, Sheu, Wayne H. -H., Lin, Yi-Ting, Tsai, Ching-Yi, Yang, Chia-Yu, Cheng, Yu-Jhen, Huang, Pau-Yi, Li, Ju-Pi, Chiu, Li-Li, Wang, Xiaohong, Xie, Min, Schneider, Michael D., Tan, Tse-Hua
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143962/
https://ncbi.nlm.nih.gov/pubmed/25098764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5602
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