Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate–dependent dioxygenase

Spliceostatins are potent spliceosome inhibitors biosynthesized by a hybrid nonribosomal peptide synthetase−polyketide synthase (NRPS−PKS) system of the trans-acyl transferase (AT) type. Burkholderia sp. FERM BP-3421 produces hemiketal spliceostatins, such as FR901464, as well as analogs containing...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Eustáquio, Alessandra S., Janso, Jeffrey E., Ratnayake, Anokha S., O’Donnell, Christopher J., Koehn, Frank E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2014
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143056/
https://ncbi.nlm.nih.gov/pubmed/25097259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408300111
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