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Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons
l-lactate is a product of aerobic glycolysis that can be used by neurons as an energy substrate. Here we report that in neurons l-lactate stimulates the expression of synaptic plasticity-related genes such as Arc, c-Fos, and Zif268 through a mechanism involving NMDA receptor activity and its downstr...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4143009/ https://ncbi.nlm.nih.gov/pubmed/25071212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322912111 |
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