Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

l-lactate is a product of aerobic glycolysis that can be used by neurons as an energy substrate. Here we report that in neurons l-lactate stimulates the expression of synaptic plasticity-related genes such as Arc, c-Fos, and Zif268 through a mechanism involving NMDA receptor activity and its downstr...

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Detaylı Bibliyografya
Asıl Yazarlar: Yang, Jiangyan, Ruchti, Evelyne, Petit, Jean-Marie, Jourdain, Pascal, Grenningloh, Gabriele, Allaman, Igor, Magistretti, Pierre J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143009/
https://ncbi.nlm.nih.gov/pubmed/25071212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322912111
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