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Glucosamine-Induced OGT Activation Mediates Glucose Production Through Cleaved Notch1 and FoxO1, Which Coordinately Contributed to the Regulation of Maintenance of Self-Renewal in Mouse Embryonic Stem Cells

We aimed to study the relationship between glucosamine and FoxO1/Notch in gluconeogenesis and maintenance of mouse embryonic stem cell (mESC) self-renewal. Glucosamine (GlcN) increased glucose production and gluconeogenic enzyme (G6Pase and PEPCK) expression. GlcN also increased the percentage of ce...

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Autori principali: Jeon, Ji Hoon, Suh, Han Na, Kim, Mi Ok, Ryu, Jung Min, Han, Ho Jae
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142796/
https://ncbi.nlm.nih.gov/pubmed/24730386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2013.0583
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