Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity()

Therapies that improve leptin sensitivity have potential as an alternative treatment approach against obesity and related comorbidities. We investigated the effects of Socs3 gene ablation in different mouse models to understand the role of SOCS3 in the regulation of leptin sensitivity, diet-induced...

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Detalhes bibliográficos
Main Authors: Pedroso, João A.B., Buonfiglio, Daniella C., Cardinali, Lais I., Furigo, Isadora C., Ramos-Lobo, Angela M., Tirapegui, Julio, Elias, Carol F., Donato, Jose
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142399/
https://ncbi.nlm.nih.gov/pubmed/25161884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.06.001
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