PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle

Defective control of lipid metabolism leading to lipotoxicity causes insulin resistance in skeletal muscle, a major factor leading to diabetes. Here, we demonstrate that perilipin (PLIN) 5 is required to couple intramyocellular triacylglycerol lipolysis with the metabolic demand for fatty acids. PLI...

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Bibliografiske detaljer
Main Authors: Mason, Rachael R., Mokhtar, Ruzaidi, Matzaris, Maria, Selathurai, Ahrathy, Kowalski, Greg M., Mokbel, Nancy, Meikle, Peter J., Bruce, Clinton R., Watt, Matthew J.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2014
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142393/
https://ncbi.nlm.nih.gov/pubmed/25161888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.06.002
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