Bcl-2 Family Proteins Are Involved in the Signal Crosstalk between Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Tumor Chemotherapy Resistance

Tumor cells overexpress antiapoptotic proteins of the Bcl-2 (B-cell leukemia/lymphoma-2) family, which can lead to both escape from cell death and resistance to chemotherapeutic drugs. Recent studies suggest that the endoplasmic reticulum (ER) can produce proapoptotic signals, amplifying the apoptot...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Su, Jing, Zhou, Lei, Xia, Mei-hui, Xu, Ye, Xiang, Xi-yan, Sun, Lian-kun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2014
Schlagworte:
Review Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142381/
https://ncbi.nlm.nih.gov/pubmed/25177684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/234370
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