Bcl-2 Family Proteins Are Involved in the Signal Crosstalk between Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Tumor Chemotherapy Resistance

Tumor cells overexpress antiapoptotic proteins of the Bcl-2 (B-cell leukemia/lymphoma-2) family, which can lead to both escape from cell death and resistance to chemotherapeutic drugs. Recent studies suggest that the endoplasmic reticulum (ER) can produce proapoptotic signals, amplifying the apoptot...

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Bibliografske podrobnosti
Main Authors: Su, Jing, Zhou, Lei, Xia, Mei-hui, Xu, Ye, Xiang, Xi-yan, Sun, Lian-kun
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2014
Teme:
Review Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142381/
https://ncbi.nlm.nih.gov/pubmed/25177684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/234370
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