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Inhibition of proteolysis in histiotrophic nutrition pathways alters DNA methylation and one-carbon metabolism in the organogenesis-stage rat conceptus
Epigenetic modifications, including DNA methylation, contribute to the transcriptional regulation of developmental genes that control growth and differentiation during embryogenesis. The methyl donor, S-adenosylmethionine (SAM) is biosynthesized from methionine and ATP by methionine adenosyltransfer...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4142195/ https://ncbi.nlm.nih.gov/pubmed/23453262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jnutbio.2012.12.007 |
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