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Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgene
Upon oxidative challenge the genome accumulates adducts and breaks that activate the DNA damage response to repair, arrest or eliminate the damaged cell. Thus, reactive oxygen species (ROS) generated by endogenous oxygen metabolism are thought to affect mutation frequency. However, few studies deter...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4141878/ https://ncbi.nlm.nih.gov/pubmed/23237310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12036 |
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