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Comparative Analysis of Functional Metagenomic Annotation and the Mappability of Short Reads

To assess the functional capacities of microbial communities, including those inhabiting the human body, shotgun metagenomic reads are often aligned to a database of known genes. Such homology-based annotation practices critically rely on the assumption that short reads can map to orthologous genes...

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Detalhes bibliográficos
Main Authors: Carr, Rogan, Borenstein, Elhanan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141809/
https://ncbi.nlm.nih.gov/pubmed/25148512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105776
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