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Inhibition of c-Abl Kinase Activity Renders Cancer Cells Highly Sensitive to Mitoxantrone

Although c-Abl has increasingly emerged as a key player in the DNA damage response, its role in this context is far from clear. We studied the effect of inhibition of c-Abl kinase activity by imatinib with chemotherapy drugs and found a striking difference in cell survival after combined mitoxantron...

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Hlavní autoři: Alpay, Kemal, Farshchian, Mehdi, Tuomela, Johanna, Sandholm, Jouko, Aittokallio, Kaappo, Siljamäki, Elina, Kallio, Marko, Kähäri, Veli-Matti, Hietanen, Sakari
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141754/
https://ncbi.nlm.nih.gov/pubmed/25148385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105526
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