A dodecylamine derivative of cyanocobalamin potently inhibits the activities of cobalamin-dependent methylmalonyl-CoA mutase and methionine synthase of Caenorhabditis elegans

In this study, we showed that cyanocobalamin dodecylamine, a ribose 5′-carbamate derivative of cyanocobalamin, was absorbed and accumulated to significant levels by Caenorhabditis elegans and was not further metabolized. The levels of methylmalonic acid and homocysteine, which serve as indicators of...

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Hlavní autoři: Bito, Tomohiro, Yabuta, Yukinori, Ichiyanagi, Tsuyoshi, Kawano, Tsuyoshi, Watanabe, Fumio
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141197/
https://ncbi.nlm.nih.gov/pubmed/25161880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2014.07.008
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