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Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice
Mice bearing germ line mutations of p53 develop sarcomas at a significant rate. Since they are susceptible to a variety of other malignancies, they are not ideally suited to the study of sarcomas. To test the possibility that targeted mutation of tumor suppressor genes in early mesenchymal cells wou...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2009
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4141195/ https://ncbi.nlm.nih.gov/pubmed/19635748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp180 |
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