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Molecular Basis of the General Base Catalysis of an α/β-Hydrolase Catalytic Triad
The serine-histidine-aspartate triad is well known for its covalent, nucleophilic catalysis in a diverse array of enzymatic transformations. Here we show that its nucleophilicity is shielded and its catalytic role is limited to being a specific general base by an open-closed conformational change in...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4140940/ https://ncbi.nlm.nih.gov/pubmed/24737327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.535641 |
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