Alteration of the Glucagon Axis in GPR120 (FFAR4) Knockout Mice: A ROLE FOR GPR120 IN GLUCAGON SECRETION

GPR40 (FFAR1) and GPR120 (FFAR4) are G-protein-coupled receptors (GPCRs) that are activated by long chain fatty acids (LCFAs). GPR40 is expressed at high levels in islets and mediates the ability of LCFAs to potentiate glucose-stimulated insulin secretion (GSIS). GPR120 is expressed at high levels i...

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Autori principali: Suckow, Arthur T., Polidori, David, Yan, Wen, Chon, Suhyoun, Ma, Jing Ying, Leonard, James, Briscoe, Celia P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140930/
https://ncbi.nlm.nih.gov/pubmed/24742677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568683
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