The Double Zinc Finger Domain and Adjacent Accessory Domain from the Transcription Factor Loss of Zinc Sensing 1 (Loz1) Are Necessary for DNA Binding and Zinc Sensing

The Loz1 transcription factor from Schizosaccharomyces pombe plays an essential role in zinc homeostasis by repressing target gene expression in zinc-replete cells. To determine how Loz1 function is regulated by zinc, we employed a genetic screen to isolate mutants with impaired zinc-dependent gene...

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Bibliografiska uppgifter
Huvudupphovsmän: Ehrensberger, Kate M., Corkins, Mark E., Choi, Sangyong, Bird, Amanda J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
Gene Regulation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140304/
https://ncbi.nlm.nih.gov/pubmed/24831008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.551333
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