Identifying USPs regulating immune signals in Drosophila: USP2 deubiquitinates Imd and promotes its degradation by interacting with the proteasome

BACKGROUND: Rapid activation of innate immune defences upon microbial infection depends on the evolutionary conserved NF-κB dependent signals which deregulation is frequently associated with chronic inflammation and oncogenesis. These signals are tightly regulated by the linkage of different kinds o...

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Autores principales: Engel, Elodie, Viargues, Perrine, Mortier, Magda, Taillebourg, Emmanuel, Couté, Yohann, Thevenon, Dominique, Fauvarque, Marie-Odile
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140012/
https://ncbi.nlm.nih.gov/pubmed/25027767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-014-0041-2
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