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The dual nature of mismatch repair as antimutator and mutator: for better or for worse

DNA is constantly under attack by a number of both exogenous and endogenous agents that challenge its integrity. Among the mechanisms that have evolved to counteract this deleterious action, mismatch repair (MMR) has specialized in removing DNA biosynthetic errors that occur when replicating the gen...

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Detalhes bibliográficos
Main Authors: Bak, Sara Thornby, Sakellariou, Despoina, Pena-Diaz, Javier
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139959/
https://ncbi.nlm.nih.gov/pubmed/25191341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2014.00287
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