Activation of a G protein-coupled receptor by its endogenous ligand triggers the Caenorhabditis elegans innate immune response

Immune defenses are triggered by microbe-associated molecular patterns or as a result of damage to host cells. The elicitors of immune responses in the nematode Caenorhabditis elegans are unclear. Using a genome-wide RNAi screen, we identify the G-protein coupled receptor (GPCR) DCAR-1 as being requ...

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Bibliographic Details
Main Authors: Zugasti, Olivier, Bose, Neelanjan, Squiban, Barbara, Belougne, Jérôme, Kurz, C. Léopold, Schroeder, Frank C., Pujol, Nathalie, Ewbank, Jonathan J.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139443/
https://ncbi.nlm.nih.gov/pubmed/25086774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2957
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