Persistent Inflammation-induced Up-regulation of Brain-derived Neurotrophic Factor (BDNF) Promotes Synaptic Delivery of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor GluA1 Subunits in Descending Pain Modulatory Circuits

The enhanced AMPA receptor phosphorylation at GluA1 serine 831 sites in the central pain-modulating system plays a pivotal role in descending pain facilitation after inflammation, but the underlying mechanisms remain unclear. We show here that, in the rat brain stem, in the nucleus raphe magnus, whi...

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Detalhes bibliográficos
Main Authors: Tao, Wenjuan, Chen, Quan, Zhou, Wenjie, Wang, Yunping, Wang, Lu, Zhang, Zhi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139232/
https://ncbi.nlm.nih.gov/pubmed/24966334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.580381
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