Targeting CB(2)-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling

The G protein-coupled receptors CB(2) (CB(2)R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB(2)R and...

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Detalhes bibliográficos
Main Authors: Moreno, Estefanía, Andradas, Clara, Medrano, Mireia, Caffarel, María M., Pérez-Gómez, Eduardo, Blasco-Benito, Sandra, Gómez-Cañas, María, Pazos, M. Ruth, Irving, Andrew J., Lluís, Carme, Canela, Enric I., Fernández-Ruiz, Javier, Guzmán, Manuel, McCormick, Peter J., Sánchez, Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139213/
https://ncbi.nlm.nih.gov/pubmed/24942731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.561761
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