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LEF-1 contains an activation domain that stimulates transcription only in a specific context of factor-binding sites.

Lymphoid enhancer factor 1 (LEF-1) is a member of the high mobility group (HMG) family of proteins and participates in the regulation of the T cell receptor (TCR) alpha enhancer. We have previously shown that DNA binding by the HMG domain of LEF-1 induces a sharp bend in the DNA helix. Together with...

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Bibliografske podrobnosti
Main Authors: Giese, K, Grosschedl, R
Format: Artigo
Jezik:Inglês
Izdano: 1993
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC413904/
https://ncbi.nlm.nih.gov/pubmed/8223476
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