THE NOVEL TUMOR SUPPRESSOR AND POLARITY GENE TRIM62 (DEAR1) SYNERGIZES WITH ONCOGENIC RAS IN INVASIVE LUNG CANCER

Deregulation of cell polarity proteins has been linked to the processes of invasion and metastasis. TRIM62, is a regulator of cell polarity and a tumor suppressor in breast cancer. Here, we demonstrate that human non-small cell lung cancer lesions show a step-wise loss of TRIM62 levels during diseas...

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Detalhes bibliográficos
Main Authors: Quintás-Cardama, Alfonso, Post, Sean M., Solis, Luisa M., Xiong, Shunbin, Yang, Peirong, Chen, Nanyue, Wistuba, Ignacio I., Killary, Ann M., Lozano, Guillermina
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138305/
https://ncbi.nlm.nih.gov/pubmed/24890125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4385
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