A Novel MicroRNA-132-Surtuin-1 Axis Underlies Aberrant B-cell Cytokine Regulation in Patients with Relapsing-Remitting Multiple Sclerosis

Clinical trial results demonstrating that B-cell depletion substantially reduces new relapses in patients with multiple sclerosis (MS) have established that B cells play a role in the pathophysiology of MS relapses. The same treatment appears not to impact antibodies directed against the central ner...

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Autors principals: Miyazaki, Yusei, Li, Rui, Rezk, Ayman, Misirliyan, Hétoum, Moore, Craig, Farooqi, Nasr, Solis, Mayra, Goiry, Lorna Galleguillos, de Faria Junior, Omar, Dang, Van Duc, Colman, David, Dhaunchak, Ajit Singh, Antel, Jack, Gommerman, Jennifer, Prat, Alexandre, Fillatreau, Simon, Bar-Or, Amit
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138149/
https://ncbi.nlm.nih.gov/pubmed/25136908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105421
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