Herpes simplex virus type-2 stimulates HIV-1 replication in cervical tissues: implications for HIV-1 transmission and efficacy of anti-HIV-1 microbicides

Herpes Simplex virus Type-2 (HSV-2) increases the risk of HIV-1 acquisition, yet the mechanism for this viral pathogen to regulate the susceptibility of the cervicovaginal mucosa to HIV-1 is virtually unknown. Using ex vivo human ectocervical tissue models, we report greater levels of HIV-1 reverse...

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Detalhes bibliográficos
Main Authors: Rollenhagen, C, Lathrop, M J, Macura, S L, Doncel, G F, Asin, S N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137741/
https://ncbi.nlm.nih.gov/pubmed/24496317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2014.3
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