Micropatterned Cell–Cell Interactions Enable Functional Encapsulation of Primary Hepatocytes in Hydrogel Microtissues

Drug-induced liver injury is a major cause of drug development failures and postmarket withdrawals. In vitro models that incorporate primary hepatocytes have been shown to be more predictive than model systems which rely on liver microsomes or hepatocellular carcinoma cell lines. Methods to phenotyp...

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Bibliographic Details
Main Authors: Li, Cheri Y., Stevens, Kelly R., Schwartz, Robert E., Alejandro, Brian S., Huang, Joanne H., Bhatia, Sangeeta N.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2014
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137334/
https://ncbi.nlm.nih.gov/pubmed/24498910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ten.tea.2013.0667
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