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The Human LINE-1 Retrotransposon Creates DNA Double-strand Breaks
Long interspersed element-1 (L1) is an autonomous retroelement that is active in the human genome. The proposed mechanism of insertion for L1 suggests that cleavage of both strands of genomic DNA is required. We demonstrate that L1 expression leads to a high level of double-strand break (DSB) format...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4136747/ https://ncbi.nlm.nih.gov/pubmed/16490214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.01.089 |
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