Efficacy and Day 7 Plasma Piperaquine Concentrations in African Children Treated for Uncomplicated Malaria with Dihydroartemisinin-Piperaquine

BACKGROUND: One promising new Artemisinin-based combination therapies (ACTs) is dihydroartemisinin-piperaquine (DHA-PQ). However, the pharmacokinetics of piperaquine and the relationship between drug levels and clinical efficacy are incompletely characterized, particularly in children. METHODS: We p...

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Detalhes bibliográficos
Main Authors: Zongo, Issaka, Somé, Fabrice A., Somda, Serge A. M., Parikh, Sunil, Rouamba, Noel, Rosenthal, Philip J., Tarning, Joel, Lindegardh, Niklas, Nosten, François, Ouédraogo, Jean Bosco
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136730/
https://ncbi.nlm.nih.gov/pubmed/25133389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103200
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