Llwytho...

Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates adaptive responses to oxygen deprivation. In addition, the HIF-1α subunit has a nontranscriptional role as a negative regulator of DNA replication through effects on minichromosome maintenance helicase loading and activation....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hubbi, Maimon E., Gilkes, Daniele M., Hu, Hongxia, Kshitiz, Ahmed, Ishrat, Semenza, Gregg L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136593/
https://ncbi.nlm.nih.gov/pubmed/25071185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412840111
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