Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence

Kaposi's sarcoma-associated herpesvirus (KSHV) latently infects tumor cells and persists as a multiple-copy, extrachromosomal, circular episome. To persist, the viral genome must replicate with each cell cycle. The KSHV latency-associated nuclear antigen (LANA) mediates viral DNA replication an...

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Detalhes bibliográficos
Main Authors: Sun, Qiming, Tsurimoto, Toshiki, Juillard, Franceline, Li, Lin, Li, Shijun, De León Vázquez, Erika, Chen, She, Kaye, Kenneth
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136584/
https://ncbi.nlm.nih.gov/pubmed/25071216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404219111
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