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5-Methylation of Cytosine in CG:CG Base-pair Steps: A Physicochemical Mechanism for the Epigenetic Control of DNA Nanomechanics

Van der Waals density functional theory is integrated with analysis of a non-redundant set of protein-DNA crystal structures from the Nucleic Acid Database to study the stacking energetics of CG:CG base-pair steps, specifically the role of cytosine 5-methylation. Principal component analysis of the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yusufaly, Tahir I., Li, Yun, Olson, Wilma K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136556/
https://ncbi.nlm.nih.gov/pubmed/24313757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp409887t
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