Reduced Skeletal Muscle Oxidative Capacity and Elevated Ceramide but not Diacylglycerol Content in Severe Obesity

OBJECTIVE: The link between a reduced capacity for skeletal muscle mitochondrial fatty acid oxidation (FAO) and lipotoxicity in human insulin resistance has been the subject of intense debate. The objective of this study was to investigate whether reduced FAO is associated with elevated acyl CoA, ce...

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Hlavní autoři: Coen, P.M., Hames, K.C., Leachman, E.M., DeLany, J.P., Ritov, V.B., Menshikova, E.V., Dubé, J.J., Stefanovic-Racic, M., Toledo, F.G.S., Goodpaster, B.H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136513/
https://ncbi.nlm.nih.gov/pubmed/23512750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/oby.20381
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