Reduced Skeletal Muscle Oxidative Capacity and Elevated Ceramide but not Diacylglycerol Content in Severe Obesity

OBJECTIVE: The link between a reduced capacity for skeletal muscle mitochondrial fatty acid oxidation (FAO) and lipotoxicity in human insulin resistance has been the subject of intense debate. The objective of this study was to investigate whether reduced FAO is associated with elevated acyl CoA, ce...

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Detalhes bibliográficos
Main Authors: Coen, P.M., Hames, K.C., Leachman, E.M., DeLany, J.P., Ritov, V.B., Menshikova, E.V., Dubé, J.J., Stefanovic-Racic, M., Toledo, F.G.S., Goodpaster, B.H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136513/
https://ncbi.nlm.nih.gov/pubmed/23512750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/oby.20381
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