Adenovirus E1A negatively and positively modulates transcription of AP-1 dependent genes by dimer-specific regulation of the DNA binding and transactivation activities of Jun.

Adenovirus E1A proteins inhibit expression of the collagenase gene but activate expression of the c-jun gene. Both effects are mediated by TPA-responsive elements (TREs), the binding sites for members of the AP-1 transcription factor family. By a process that is independent of the retinoblastoma gen...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Hagmeyer, B M, König, H, Herr, I, Offringa, R, Zantema, A, van der Eb, A, Herrlich, P, Angel, P
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413632/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8253081/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb06030.x
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