Intranasal P Particle Vaccine Provided Partial Cross-Variant Protection against Human GII.4 Norovirus Diarrhea in Gnotobiotic Pigs

Noroviruses (NoVs) are the leading cause of nonbacterial acute gastroenteritis worldwide in people of all ages. The P particle is a novel vaccine candidate derived from the protruding (P) domain of the NoV VP1 capsid protein. This study utilized the neonatal gnotobiotic pig model to evaluate the pro...

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Autores principales: Kocher, Jacob, Bui, Tammy, Giri-Rachman, Ernawati, Wen, Ke, Li, Guohua, Yang, Xingdong, Liu, Fangning, Tan, Ming, Xia, Ming, Zhong, Weiming, Jiang, Xi, Yuan, Lijuan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136312/
https://ncbi.nlm.nih.gov/pubmed/24920797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01249-14
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