Inter-species chimeras of leukaemia inhibitory factor define a major human receptor-binding determinant.

Human leukaemia inhibitory factor (hLIF) binds to both human and mouse LIF receptors (LIF-R), while mouse LIF (mLIF) binds only to mouse LIF-R. Moreover, hLIF binds with higher affinity to the mLIF-R than does mLIF. In order to define the regions of the hLIF molecule responsible for species-specific...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Owczarek, C M, Layton, M J, Metcalf, D, Lock, P, Willson, T A, Gough, N M, Nicola, N A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413625/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8253075/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb06023.x
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