Complement Factor C5 but Not C3 Contributes Significantly to Hydrosalpinx Development in Mice Infected with Chlamydia muridarum

Hydrosalpinx is a pathological hallmark of tubal infertility associated with chlamydial infection. However, the mechanisms of hydrosalpinx remain unknown. Here, we report that complement factor 5 (C5) contributes significantly to chlamydial induction of hydrosalpinx. Mice lacking C5 (C5(−/−)) failed...

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Bibliografiska uppgifter
Huvudupphovsmän: Yang, Zhangsheng, Conrad, Turner, Zhou, Zhou, Chen, Jianlin, Dutow, Pavel, Klos, Andreas, Zhong, Guangming
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2014
Ämnen:
Bacterial Infections
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136226/
https://ncbi.nlm.nih.gov/pubmed/24842924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01833-14
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