Host Defense Peptide Resistance Contributes to Colonization and Maximal Intestinal Pathology by Crohn's Disease-Associated Adherent-Invasive Escherichia coli

Host defense peptides secreted by colonocytes and Paneth cells play a key role in innate host defenses in the gut. In Crohn's disease, the burden of tissue-associated Escherichia coli commonly increases at epithelial surfaces where host defense peptides concentrate, suggesting that this bacteri...

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Bibliographic Details
Main Authors: McPhee, Joseph B., Small, Cherrie L., Reid-Yu, Sarah A., Brannon, John R., Le Moual, Hervé, Coombes, Brian K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136195/
https://ncbi.nlm.nih.gov/pubmed/24866805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01888-14
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