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Activity of Daptomycin or Linezolid in Combination with Rifampin or Gentamicin against Biofilm-Forming Enterococcus faecalis or E. faecium in an In Vitro Pharmacodynamic Model Using Simulated Endocardial Vegetations and an In Vivo Survival Assay Using Galleria mellonella Larvae

Enterococci are the third most frequent cause of infective endocarditis. A high-inoculum stationary-phase in vitro pharmacodynamic model with simulated endocardial vegetations was used to simulate the human pharmacokinetics of daptomycin at 6 or 10 mg/kg of body weight/day or linezolid at 600 mg eve...

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Autors principals: Luther, Megan K., Arvanitis, Marios, Mylonakis, Eleftherios, LaPlante, Kerry L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136052/
https://ncbi.nlm.nih.gov/pubmed/24867993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02790-13
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