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Blocking Herpes Simplex Virus 2 Glycoprotein E Immune Evasion as an Approach To Enhance Efficacy of a Trivalent Subunit Antigen Vaccine for Genital Herpes

Herpes simplex virus 2 (HSV-2) subunit antigen vaccines targeting virus entry molecules have failed to prevent genital herpes in human trials. Our approach is to include a virus entry molecule and add antigens that block HSV-2 immune evasion. HSV-2 glycoprotein C (gC2) is an immune evasion molecule...

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Hlavní autoři: Awasthi, Sita, Huang, Jialing, Shaw, Carolyn, Friedman, Harvey M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135967/
https://ncbi.nlm.nih.gov/pubmed/24829358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01130-14
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