Determining the Epitope Dominance on the Capsid of a Serotype SAT2 Foot-and-Mouth Disease Virus by Mutational Analyses

Monoclonal-antibody (MAb)-resistant mutants were used to map antigenic sites on foot-and-mouth disease virus (FMDV), which resulted in the identification of neutralizing epitopes in the flexible βG-βH loop in VP1. For FMDV SAT2 viruses, studies have shown that at least two antigenic sites exist. By...

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Detalhes bibliográficos
Main Authors: Opperman, Pamela A., Rotherham, Lia S., Esterhuysen, Jan, Charleston, Bryan, Juleff, Nicholas, Capozzo, Alejandra V., Theron, Jacques, Maree, Francois F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135947/
https://ncbi.nlm.nih.gov/pubmed/24829347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00470-14
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