Using Pharmacokinetic and Viral Kinetic Modeling To Estimate the Antiviral Effectiveness of Telaprevir, Boceprevir, and Pegylated Interferon during Triple Therapy in Treatment-Experienced Hepatitis C Virus-Infected Cirrhotic Patients

Triple therapy combining a protease inhibitor (PI) (telaprevir or boceprevir), pegylated interferon (PEG-IFN), and ribavirin (RBV) has dramatically increased the chance of eradicating hepatitis C virus (HCV). However, the efficacy of this treatment remains suboptimal in cirrhotic treatment-experienc...

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Hauptverfasser: Laouénan, Cédric, Marcellin, Patrick, Lapalus, Martine, Khelifa-Mouri, Feryel, Boyer, Nathalie, Zoulim, Fabien, Serfaty, Lawrence, Bronowicki, Jean-Pierre, Martinot-Peignoux, Michelle, Lada, Olivier, Asselah, Tarik, Dorival, Céline, Hézode, Christophe, Carrat, Fabrice, Nicot, Florence, Peytavin, Gilles, Mentré, France, Guedj, Jeremie
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135822/
https://ncbi.nlm.nih.gov/pubmed/24982076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02611-14
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