Regulatory B cells are numerically but not functionally deficient in anti-neutrophil cytoplasm antibody-associated vasculitis

Objectives. B cells are central to the pathology of ANCA-associated vasculitis (AAV), a disease characterized by autoantibodies and effectively treated by rituximab. In addition to promoting inflammation, a subset of B cells act to suppress harmful autoimmune responses (Breg). The balance of effecto...

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Bibliographische Detailangaben
Hauptverfasser: Todd, Sarah Katrina, Pepper, Ruth J., Draibe, Juliana, Tanna, Anisha, Pusey, Charles D., Mauri, Claudia, Salama, Alan D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Basic & Translational Science
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135583/
https://ncbi.nlm.nih.gov/pubmed/24729396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/keu136
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